Aurelio Andreazzoli made three changes from the side that beat Atalanta last week with Alessio Romagnoli handed a full debut in place of Marquinhos and Francesco Totti and Daniele De Rossi coming in for Michael Bradley and Marquinho. Davide Ballardini also made three changes, Cesare Bovo introduced in place of the suspended Andreas Granqvist and Eros Pisano and Daniel Tozser in place of Francelino Matuzalem and Marco Rossi.
The match began with both sides probing but not committing too much forward too early, Juraj Kucka forcing the first save of the match out of Maarten Stekelenburg with a long range effort that the Dutchman had to tip round the post.
Roma were the first team to settle into the match and began to take control, Vassilis Torosidis providing an outlet down the right hand side. Torosidis nearly provided a chance for the home side, ghosting down the right hand side and firing across the six yard box, but neither Pablo Osvaldo nor Francesco Totti had made the run which would've provided them with the simplest of finishes.
On 16 minutes, Roma took the lead. Daniele De Rossi went on an uncharacteristic mazy run into the box and collided with the knee of Cesare Bovo, sending De Rossi crashing to the ground. It looked like an accidental collision however the referee pointed to the spot without hesitation, and Francesco Totti calmly converted the penalty to become the joint second highest Serie A goalscorer of all time, joining Gunnar Nordahl on 225 goals.
Conceding seemed to galvanise Genoa and they began to pour forward without creating any really meaningful opportunities. They pressured Roma into conceding a series of corners, 11 in total in the first half without a single one at the other end.
Opportunities began to present themselves for the Grifone, Andrea Bertolacci forcing a great save from Stekelenburg with a header from all of 16 yards after Marco Borriello made it to the byeline in the left channel. The resulting corner forced another smart save from the Dutch goalkeeper after a scramble in the box.
Genoa got the goal their pressure deserved three minutes before the break, the lively Borriello breaking into the box and being hacked down by a reckless Nicolas Burdisso challenge giving referee Andrea Gervasoni the easies decision of the evening. Borriello dusted himself off to convert the spot-kick, his first goal against a former club in Serie A.
The second half was as open as the first as both sides looked to carve out an advantage, the first chance after the break coming after a jinking run from Erik Lamela, his shot eventually deflected wide by Daniele Portanova. The resulting corner was to give Roma the lead, 18 year-old Alessio Romagnoli rising to head past Sebastien Frey to give himself a full debut to remember.
Ciro Immobile was introduced for Daniel Tozser and he was causing the Roma defence headaches with his running in the channels. On one of his many enterprising runs he managed to feed Andrea Bertolacci, forcing yet another save from the peppered Stekelenburg.
Juraj Kucka forced yet another save from the Roma 'keeper, the rebound falling to Roma substitute Marquinho outside the area. Kucka made a heavy challenge on the Brazilian and the referee saw fit to show the Slovakian his second yellow card.
Genoa continued to attempt to attack following the demotion to ten men however Roma were able to deal with their forays forward without too much trouble and the points were secured when two veterans combined a minute from time, Francesco Totti's low cross was met by Simone Perrotta at the near post and the finish left Sebastien Frey with no chance to further improve Aurelio Andreazzoli's record as Roma boss.
Roma: Stekelenburg; Piris, Burdisso, Romagnoli; Torosidis, De Rossi, Pjanic (Bradley 39), Balzaretti (Marquinho 56); Lamela, Totti; Osvaldo (Perrotta 81)
Genoa: Frey; Bovo, Portanova, Moretti; Pisano (Jorquera 61), Kucka, Vargas, Tozser (Immobile 61), Antonelli; Bertolacci (Rigoni 72); Borriello
Goals: Totti pen 16 (R), Borriello pen 42 (G), Romagnoli 58 (R), Perrotta 89 (R)
Sent off: Kucka 78 (G)