Alexander Buttner comes in at left-back while Shinji Kagawa starts behind Robin van Persie. Chris Smalling also starts in defence alongside Nemanja Vidic, although Robin van Persie, Rafael and Michael Carrick are all still in the side.
Sunderland meanwhile start with Danny Graham up front in the absence of the injured Steven Fletcher. Stephane Sessegnon plays just behind him, and Craig Gardner returns to midfield, with Phil Bardsley coming in at right-back.
Manchester United starting line-up (4-5-1): David De Gea; Rafael, Chris Smalling, Nemanja Vidic, Alexander Buttner; Antonio Valencia, Michael Carrick, Anderson, Ashley Young, Shinji Kagawa; Robin van Persie.
Sunderland starting line-up (4-4-1-1): Simon Mignolet; Phil Bardsley, Danny Rose, John O'Shea, Titus Bramble; Alfred N'Diaye, Craig Gardner, James McClean, Adam Johnson; Stephane Sessegnon; Danny Graham.