West Ham may not quite be safe from the relegation battle just yet, but they are far enough away that all the attention will be on Manchester United's ability to take another big step towards wrapping up the title.
The Red Devils may be in a virtually-impregnable position at the top of the table, but their rivals will surely still hold any hope for them to slip up, and with United playing their second game in four days, may rotate players for the occasion. United's 2-0 victory at Stoke on Sunday was relatively straightforward, but they should find the Hammers to be sterner opposition.
WIth Robin van Persie breaking his goalless streak, he may now find the statistic simply repeated with the words "...from open play" tacked on, and will have a chance to end that if he starts. Wayne Rooney could also reprise his role in midfield. Whatever team United send it, it should be capable of securing victory.
West Ham United injuries and suspensions
Manchester United injuries and suspensions
West Ham will give fitness tests to Noble and Tomkins to see if the home-grown duo will be able to play a part in the game, but otherwise have no new injuries.
Manchester United could welcome back Rafael but will be without Ashley Young as well as Paul Scholes.
Match Date\Time: Wednesday, 7:45 p.m.
Venue: The Boleyn Ground, London, England
TV: ESPN 2, ESPN Deportes (U.S.), Sky Sports 2 (UK), TDN (Canada)
Online: ESPN 3 (U.S.), Sky Go (U.K.)