The Biancocelesti have rediscovered their form in the last seven days, thrashing Bologna 6-0 last Sunday, before defeating Inter Milan 3-1 at the San Siro in midweek, to put them back in the Europa League mix.
Despite the pressure being off, Rossi will be hopeful of arresting his side's slump and getting one over his former employers. Before Wednesday's victory over Inter, Lazio's previous away win came just before Christmas at Sampdoria, ruining Rossi's debut on the Blucerchiati bench.
Lazio midfielder Cristian Brocchi announced his retirement on Friday after a metatarsal break suffered in February. A pulled thigh muscle also benches Michael Ciani. Ederson and Stefano Mauri remain sidelined, while Abdoulay Konko and Andre Dias face fitness tests.
While Sampdoria have had the better of recent games between the two sides in Genoa, you have to go back eight years for the last time they won in Rome. The last six meetings in the Eternal City have primarily gone the way of the hosts - five wins and a draw.
Lazio injuries and suspensions
Out: Michael Ciani, Ederson, Stefano Mauri (injured) Abdoulay Konko, Andre Dias (in doubt)
Sampdoria injuries and suspensions
Out: Nenad Krsticic (injured) Andrea Costa (in doubt)
Match Date/Time: Sunday 12th May 2013 3:00 p.m. local, 9:00 a.m. ET
Venue: Stadio Olimpico, Rome, Italy
TV: Sky Calcio 2 (Italy)