Podolski starts up front with Theo Walcott, Tomas Rosicky and Santiago Cazorla behind, with Jack Wilshere dropped to the bench for the game. Kieran Gibbs also starts at left-back in place of Nacho Monreal.
Newcastle, meanwhile, name Mapou Yanga-Mbiwa at left-back, with Papiss Cisse and Yoann Gouffran both starting up front. Veteran keeper Steve Harper, who plays his last game in a Newcastle shirt, will captain the side instead of Fabricio Coloccini as a farewell gesture.
Arsenal starting line-up (4-2-3-1): Wojciech Szczesny; Bacary Sagna, Per Mertesacker, Laurent Koscielny, Kieran Gibbs; Aaron Ramsey, Mikel Arteta; Theo Walcott, Tomas Rosicky, Santiago Cazorla; Lukas Podolski.
Newcastle United starting line-up (4-4-2): Steve Harper; Mathieu Debuchy, Steven Taylor, Fabricio Coloccini, Mapou Yanga-Mbiwa; Cheik Tiote, Yohan Cabaye, Jonas Gutierrez, Hatem Ben Arfa; Papiss Cisse, Yoann Gouffran.