Although neither side currently occupy any of the relegation places, both sides remain perilously close to the drop zone. Torino are a point above their visitors, who hold a three point gap over Palermo.
Whereas Genoa have found some form, picking up eight points from a possible 12, including two wins on the bounce, Torino are the polar opposite. The Granata have hit the skids at the worst possible time and come into the game on the back of four consecutive defeats.
After losing a seven goal thriller at Fiorentina and coming up short in the Turin derby, Giampiero Ventura's side put in a battling display at AC Milan on Sunday, only to fall to a late Mario Balotelli strike. One win will secure their Serie A status for another season, but on current form, that's easier said than done.
Genoa recorded their biggest victory of the season on Sunday when they defeated Pescara 4-1 and sent them to Serie B. Marco Borriello's brace moved him up to 12 for the season and confidence will be high in the Grifone camp.
Torino welcome Kamil Glik back from suspension, while Alen Stevanovic is the only notable absentee with a back injury.
The two sides played out a 1-1 draw at the Marassi back in December. Torino last won this fixture over eight years ago when both teams were in Serie B.
Torino injuries and suspensions
Out: Alen Stevanovic (injured)
Genoa injuries and suspensions
Out: Damiano Ferronetti, Ruben Olivera, Juraj Kucka, Marco Rossi (injured)
Match Date/Time: Wednesday 8th May 2013 8:45 p.m. local, 2:45 p.m. ET
Venue: Stadio Olimpico, Turin, Italy
TV: Sky Calcio 5 (Italy)