The Japanese playmaker had been rumoured to be unfancied by David Moyes, but he starts in midfield along with new signing Fellaini. Rafael is still absent with injury, with Chris Smalling in his place rather than Phil Jones. Wayne Rooney starts in the number 10 role, however, with Kagawa moved out to the left.
Bayer, meanwhile, line up with Emre Can and Simon Rolfes in a solid-looking base, with Son Heung-Min the playmaker just ahead. Stefan Kiessling leads the line up front on his own.
Manchester United starting line-up: David De Gea; Chris Smalling, Rio Ferdinand, Nemanja Vidic, Patrice Evra; Michael Carrick, Marouane Fellaini; Antonio Valencia, Shinji Kagawa Wayne Rooney; Robin van Persie.
Bayer Leverkusen starting line-up: Bernd Leno, Emir Spahic, Sebastian Boenisch, Omer Toprak, Giulio Donati, Stefan Reinartz, Simon Rolfes, Emre Can, Sidnei Sam, Son Heung-Min, Stefan Kiessling