Antonio Conte's side retained their eight point lead at the top of Serie A by coming out on top in this six goal thriller at the Juventus Stadium. Samp had completed the league double over the reigning champions last season, but this time around the tables have been turned.
Arturo Vidal and Fernando Llorente set Juve on their way before Andrea Barzagli put through his own net to give Sampdoria hope. Vidal's penalty restored the two goal cushion, but Manolo Gabbiadini brought Sampdoria back into it. Paul Pogba settled the game once and for all with a wonder strike.
Nenad Krsticic and Roberto Soriano were suspended for the visitors, but Pedro Obiang was back from a ban and Gabbiadini faced his parent club. Samp were the last Italian side to win at the Juventus Stadium just over a year ago.
Inside the opening minutes, Kwadwo Asamoah was found in acres of space out wide. The winger wasted the chance, as he screwed a weak shot which was easily saved by a grateful Angelo Da Costa.
Juve continued to create the early chances. Pogba used his long legs to bring down a deep cross, then teed up Giorgio Chiellini to smash a pair of volleys into the blue wall. Tevez muscled between two markers to hook a shot wide of the upright.
The home side took the lead on 18 minutes. Pogba's disguised pass found Vidal, who used the outside of his boot to flick the ball past Da Costa.
Samp took the game to their hosts. Gabbiadini tried his luck from distance, then brought a save out of Gianluigi Buffon with a volley on the turn. It wouldn't have counted, as play was brought back for an offside flag. Daniele Gastaldello saw a free header from a corner loop over the bar.
Just six minutes after hitting the front, Juve doubled their lead. Llorente peeled off his marker to meet a corner and send a bullet header into the roof of the net.
Once again, the Blucerchiati refused to be dispirited. Gabbiadini saw a shot charged down from a corner and Shkodran Mustafi forced Buffon into a save with his legs.
The woodwork prevented Samp from going further behind. Tevez met Vidal's pull back and the Argentine's snapshot ricocheted off the post.
Chiellini brought down Gabbiadini on the edge of the box, but the attacker wasted the resulting free kick, opting for power and rifling the ball into the stands. Sampdoria were given a way back into the match, courtesy of an own goal seven minutes before half time. Gabbiadini's teasing ball across the six yard box was turned in by a sliding Barzagli. It was the first goal Juventus had conceded in seven home games.
Three minutes later, Juve were awarded a penalty after Vasco Regini clipped Vidal in the box. The Chilean stepped up and smashed the ball into the top corner to restore the Old Lady's two goal cushion.
The away side dominated possession for much of the second half and remained dangerous from set plays. Buffon showed cat like reflexes to keep out De Silvestri's header after Llorente lost his marker on a corner. The Spaniard then wasted a glorious chance to put the game beyond Samp, rushing to shoot wide when put clean through on goal.
Juventus didn't heed the warning from corners and Samp pulled the game back once more. Regini's header was kept out by Buffon, who was powerless to stop Gabbiadini from rolling in the rebound. The game was set for a grandstand final 20 minutes. Gabbiadini almost drew the sides level, but his curler from distance rattled the crossbar.
Conte's team netted the deciding goal out of nothing on 78 minutes. Pogba pulled the trigger from the edge of the area and the ball curled up and over a diving Da Costa. It was a moment of genius from the 20-year-old Frenchman. The goal deflated the plucky Sampdoria players and Pogba almost snatched a fifth late on. He collected a Fabio Quagliarella pass and hit the ball first time, only to see his effort finish the wrong side of the far post.
Juventus: Buffon; Barzagli, Ogbonna, Chiellini; Lichtsteiner, Vidal, Marchisio, Pogba, Asamoah; (Peluso 80) Tevez, (Giovinco 86) Llorente (Quagliarella 86)
Sampdoria: Da Costa; De Silvestri, Mustafi, (Costa 52) Gastaldello, Regini; Palombo, Obiang; Gabbiadini, Bjarnason, (Renan 46) Wszolek; (Sansone 70) Eder
Goals: Vidal 18, pen 41 (J) Llorente 24 (J) Barzagli og 38 (S) Gabbiadini 70 (S) Pogba 78 (J)