This is the second time this month the two teams will have met, with one more game coming next week in the second leg. Madrid one of the meeting -- a league match -- 1-0 thanks to a header from Pepe early in the second half. Espanyol will be hoping to take some positives away from that result and find a way to upset Los Blancos.
Carlo Ancelotti will likely shift is lineup around again in an attempt to keep players fresh. Sergio Ramos is doubtful with a knee injury and Xabi Alonso will probably be rested, opening up a spot for Asier Illarramendi. Karim Benzema scored his 100th goal in a Madrid jersey over the weekend but might find himself back on the bench in favor of Jesé.
Espanyol injuries and suspensions
Out: David López (hamstring)
Real Madrid injuries and suspensions
Varane is back training for Madrid but is not yet ready to play in a match. Facio Coentraão is suspended after picking up a red card in Madrid's win over Real Betis.
Espanyol: Kiko Casilla, Javi López, Diego Colotto, Héctor Moreno, Juan Fuentes, Raúl Rodriguez, Gabriel Torje, Victor Sánchez, Álex Fernández, Christian Stuani, Jhon Córdoba.
Match Date/Time: 9 p.m. local, 3 p.m. ET
Venue: Estadi Cornellà-El Prat, Barcelona, Spain
TV: NBC Sports Network (U.S.), Sky Sports 2 (U.K.)
Online: beIN Sports Play (U.S.), Sky Go (U.K).