The Gunners are suffering from several injury problems, and Thomas Vermaelen partners Laurent Koscielny in central defence with Serge Gnabry starting in midfield alongside Mikel Arteta and Jack Wilshere. Santiago Cazorla and Tomas Rosicky are on the wings for Arsene Wenger's men.
Tottenham, meanwhile, continue with their 4-4-2 system, with Nabil Bentaleb starting in midfield instead of Etienne Capoue. Vladimir Chiriches partners Michael Dawson in central defence, with Danny Rose continuing at left-back and former Gunner Emmanuel Adebayor partnering Roberto Soldado up front.
Arsenal starting line-up (4-3-3): Lukasz Fabianski; Bacary Sagna, Laurent Koscielny, Thomas Vermaelen, Nacho Monreal; Serge Gnabry, Mikel Arteta, Jack Wilshere; Santi Cazorla, Theo Walcott, Tomas Rosicky.
Tottenham Hotspur starting lineup (4-4-2): Hugo Lloris; Kyle Walker, Vladimir Chiriches, Michael Dawson, Danny Rose; Aaron Lennon, Nabil Bentaleb, Moussa Dembele, Christian Eriksen; Emmanuel Adebayor, Roberto Soldado.