Manchester United will welcome last-placed Fulham to Old Trafford hoping to get back in the win column after picking up their eight loss of the season last week against Stoke City.
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David Moyes will have some decision to make in the central defense with Jonny Evans and Phil Jones likely to be unavailable. Rio Ferdinand is closer to a return but may not be ready to start, which leaves the pair of Chris Smalling and Nemanja Vidic as the likely starters. The attack should be in good shape with Robin Van Persie, Wayne Rooney and Juan Mata all expected to start.
Pressure is building Rene Meulensteen as Fulham remained stuck at the bottom of the table, but he'll be able to welcome a couple new signings into the starting eleven this week in hopes they can give his side a boost. New striker Konstantinos Mitroglou and defender John Heitinga are both expected to make their debuts for the Cottagers who are desperate for points.
Manchester United injuries and suspensions
Out: Jonny Evans (calf), Nani (hamstring). In Doubt: Rio Ferdinand (knee), Phil Jones (concussion)
Fulham injuries and suspensions
Out: John Arne Riise (hamstring), Neil Etheridge(thigh), Matthew Briggs (groin). In Doubt: Kieran Richardson (ankle)
Evans and Nani are out for United but defenders Rio Ferdinand and Phil Jones could be available depending on how pre-match tests go. Fulham will be without a trio of players but could see Kieran Richardson make his return from an ankle injury.
Projected lineups
Manchester United: David De Gea, Rafael, Chris Smalling, Nemanja Vidic, Patrice Evra, Michael Carrick, Tom Cleverly, Juan Mata, Wayne Rooney, Ashley Young, Robin Van Persie
Fulham: Maarten Stekelenburg, Sascha Reither, Brede Hangeland, Handeland, John Heitinga, Kieron Richardson, Scott Parker, William Kvist, Steve Sidwell, Lewis Holtby, Damian Duff, Darren Bent
Match Date/Time: 4 p.m. local, 11:00 a.m. ET
Venue: Old Trafford, Manchester, England
TV: USA Network (U.S.), Sky Sports 1 (U.K.), TSN2 (Canada)
Online: NBC Live Extra (U.S.), Sky Go (U.K.)