David Moyes has stuck with the same team for most of his Manchester United tenure, but he looks to be switching up his formation, going with an apparent 4-3-3. Michael Carrick, Tom Cleverley and Marouane Fellaini all start, with Danny Welbeck likely lining up as a left forward. However, it is possible Moyes could use his usual 4-2-3-1 formation with Fellaini as an attacking midfielder.
Manchester City have gone with a conventional team, though the absence of Sergio Aguero means that David Silva has to play in the center, not his usual left wing spot. Edin Dzeko is preferred up top to Alvaro Negredo.
Kickoff is at 7:45 p.m. local time, 3:45 p.m. ET from Old Trafford. You can catch the game on Sky Sports 1 in the UK, NBC Sports Network in the US and TSN in Canada.