Star striker Edinson Cavani will not be playing as he recuperates from injury, although he did enjoy a goalscoring return at the weekend, coming off the bench to score in Paris Saint-Germain's 2-0 victory over Marseille.
With Luis Suarez in red-hot form, Uruguay are not exactly short of a goalscoring striker in his absence, although Abel Hernandez, another potential option is also missing through injury.
Austria missed out on qualifying for the World Cup but have a decent record in Austria, where they have lost just 3 of the last 13 matches, and will look to build on that home form and try out new tactics as they prepare for their Euro 2016 qualification campaign.
Match Date/Time: 8:30 p.m. local, 2:30 p.m. ET
Venue: Wörthersee Stadion, Klagenfurt am Wörthersee
TV: ORF 1 (Austria), VTV (Uruguay)