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The week has come for Alabama to get revenge for its loss to Ole Miss last season, and the Crimson Tide are home favorites by more than a touchdown, according to OddsShark. The Rebels have looked solid in dominating two cupcakes to open the season, but Alabama has arguably the most talented team in the country, and the Tide were dominant in their big opener against Wisconsin.
There are plenty of snoozers this week as non-conference season rolls on — Oregon will spot Georgia State almost 50 points — but there are some intriguing lines to watch. After a scare against Jacksonville State, Auburn opens as a 6.5-point underdog at LSU, which just won at Mississippi State. Despite losing Malik Zaire for the season and needing last-second heroics against Virginia, Notre Dame is a two-point favorite against Georgia Tech and its high-powered offense. And oh, how Texas has fallen. The Longhorns were dominated by Notre Dame in week one and looked lackluster against Rice in week two, and now they are home underdogs to Cal in week three.
We will update as more lines come in.
| Game | Favorite | Spread |
| Georgia State at Oregon | Oregon | 48.5 |
| SMU at TCU | TCU | 38 |
| Tulsa at Oklahoma | Oklahoma | 33 |
| Northern Illinois at Ohio State | Ohio State | 31.5 |
| Air Force at Michigan State | Michigan State | 27.5 |
| Nevada at Texas A&M | Texas A&M | 25 |
| UTSA at Oklahoma State | Oklahoma State | 24.5 |
| New Mexico at Arizona State | Arizona State | 24 |
| UConn at Missouri | Missouri | 24 |
| Kent State at Minnesota | Minnesota | 23 |
| Charlotte at Middle Tennessee | Middle Tennessee | 19.5 |
| Cincinnati at Miami (Ohio) | Cincinnati | 19 |
| South Carolina at Georgia | Georgia | 15.5 |
| South Alabama at San Diego State | San Diego State | 15.5 |
| NC State at Old Dominion | NC State | 15 |
| BYU at UCLA | UCLA | 14.5 |
| Louisiana Tech at Kansas State | Kansas State | 11 |
| Florida State at Boston College | Florida State | 10.5 |
| Texas Tech at Arkansas | Arkansas | 10.5 |
| Temple at UMass | Temple | 9 |
| Ole Miss at Alabama | Alabama | 8.5 |
| Stanford at USC | USC | 8 |
| San Jose State at Oregon State | Oregon State | 8 |
| South Florida at Maryland | Maryland | 7.5 |
| Illinois at North Carolina | North Carolina | 7 |
| Rutgers at Penn State | Penn State | 7 |
| Auburn at LSU | LSU | 6.5 |
| Iowa State at Toledo | Toledo | 6.5 |
| Central Michigan at Syracuse | Syracuse | 6 |
| Rice at North Texas | Rice | 6 |
| Ball State at Eastern Michigan | Ball State | 6 |
| Virginia Tech at Purdue | Virginia Tech | 5.5 |
| Nebraska at Miami | Miami | 4.5 |
| Florida at Kentucky | Florida | 4.5 |
| Memphis at Bowling Green | Memphis | 4 |
| UTEP at New Mexico State | UTEP | 4 |
| Utah State at Washington | Washington | 3.5 |
| Pitt at Iowa | Iowa | 3 |
| Western Kentucky at Indiana | Indiana | 3 |
| Northwestern at Duke | Duke | 2.5 |
| Cal at Texas | Cal | 2.5 |
| Wake Forest at Army | Wake Forest | 2 |
| Georgia Tech at Notre Dame | Notre Dame | 2 |
| Southern Miss at Texas State | Texas State | 2 |
| East Carolina at Navy | Navy | 1.5 |
| Colorado at Colorado State | Colorado State | 1 |
| Clemson at Louisville | N/A | Even |