The Mississippi Rebels are 1-5 straight up and against the spread over their last six games on the road. The Rebels face one of the toughest road trips in all of college football this Saturday when they visit the Alabama Crimson Tide in Tuscaloosa.
Ole Miss is a 6.5-point road underdog according to sportsbooks monitored by OddsShark.com. Mississippi has racked up an impressive 149 points through its first two games of the season, but being on the road at Alabama will be a much tougher challenge than games at home against Tennessee-Martin and Fresno State.
The Crimson Tide are a perfect 29-0 SU in their last 29 games played in September.
The Notre Dame Fighting Irish suffered a big blow on Saturday when quarterback Malik Zaire was lost for the season due to a broken ankle. The Fighting Irish opened as a two-point home favorite this week hosting the red hot Georgia Tech Yellow Jackets, but that line quickly shifted to Georgia Tech -2.
Notre Dame is 3-1 SU and ATS in its last four games as a home underdog and will turn to sophomore quarterback Deshone Kizer to take over under center.
College Football Week 3 Betting Lines
Northern Illinois at Ohio State -32.5
Stanford at USC -9.5
Auburn at LSU -7
Ole Miss at Alabama -6.5
Georgia Tech -2 at Notre Dame
After surviving an overtime scare against the Jacksonville State Gamecocks, the Auburn Tigers will need to get their act together in a hurry going up against the LSU Tigers on the road this Saturday.
LSU held off Mississippi State for a 21-19 road win last week and opens as a seven-point favorite at home this Saturday. Auburn is 4-1 ATS in its last five games against LSU with two outright wins according to the OddsShark College Football Database.
The USC Trojans have looked sharp in getting out to a 2-0 SU and ATS start to the season, blowing out Arkansas State 55-6 and Idaho 59-9. The Trojans will get their first real test of the young season this Saturday at the Coliseum when they host the Stanford Cardinal.
USC is a 9.5-point favorite over the Cardinal, who failed their first road test of the season in a 16-6 loss at Northwestern.
And finally, Ohio State will once again be a huge favorite at home against an overmatched opponent. The Buckeyes host Northern Illinois on Saturday and are going off at -32.5 at Ohio Stadium.