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College football odds and lines, Week 3: FSU, Ohio State among big-game favorites

Florida State at Louisville and Ohio State at Oklahoma highlight a loaded Week 3 card of college football betting matchups at the sportsbooks.

Glenn Beil-USA TODAY Sports

The Louisville Cardinals are 5-2 straight up and 2-5 against the spread in their last seven games against opponents in the ACC. The Cardinals will try to pick up a big conference win this Saturday against the Florida State Seminoles.

Louisville is going off as a 3.5-point home underdog on Saturday afternoon at sportsbooks monitored by Through the first two games of the season, Louisville's offense has been electric, averaging 66 points per game. Florida State has won three of its last four games against the Cardinals, including a 41-21 win at home last season.

The Ohio State Buckeyes face an extremely tough out of conference test on Saturday night when they visit Norman to take on the Oklahoma Sooners. Oklahoma suffered a shocking road loss to the Houston Cougars in their season opener, but bounced back with a 59-17 win against Louisiana Monroe last week.

Both of these teams are strong in the month of September, with Oklahoma going 7-3 ATS in its last 10 September games, and Ohio State going 10-4 ATS in its last 14. Ohio State is an early 2.5-point favorite.

College Football Week 3 Betting Lines (see the complete list at

  • Alabama (-9.5) at Ole Miss
  • Houston (-7.5) at Cincinnati
  • Michigan State at Notre Dame (-7.5)
  • Georgia (-6.5) at Missouri
  • USC at Stanford (-6.5)
  • Miami (-4.5) at Appalachian State
  • Texas A&M at Auburn (-4)
  • Florida State (-3.5) at Louisville
  • Oregon at Nebraska (-3)
  • Ohio State (-2.5) at Oklahoma

Like Oklahoma, the Notre Dame Fighting Irish lost on the road in their season opener, falling 50-47 to the Texas Longhorns. The Fighting Irish will likely have to win out from this point forward to play their way into a playoff spot, and they'll get a solid team at home this Saturday hosting the Michigan State Spartans.

Michigan State is 7-1-1 ATS in its last nine games against Notre Dame, but the home team is 5-1 SU in the last six meetings between the Fighting Irish and the Spartans, per the OddsShark College Football Database. Notre Dame is a 7.5-point favorite in this one.

The Stanford Cardinal are 10-0 SU and 9-1 ATS in their last 10 games after winning the previous game in a matchup. Stanford has won each of the last two games against the USC Trojans, scoring 41 points in each of its matchups with the Trojans last season.

USC was demolished by Alabama in its season-opening 52-6 loss to the Crimson Tide, but looked much sharper in last Saturday's 45-7 win over Utah State. The Trojans are 6.5-point underdogs on the road.