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Florida State vs. Louisville 2016 odds: Seminoles favored in Top 10 showdown

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The Florida State Seminoles and the Louisville Cardinals clash in an important ACC matchup on Saturday, with FSU the slim odds favorite.

Kim Klement-USA TODAY Sports

The Florida State Seminoles are 24-2 straight up and 15-11 against the spread in their last 26 games against ACC opponents. The Seminoles will look for another conference win this Saturday afternoon on the road against the Louisville Cardinals.

Florida State is a 1-point road favorite in Louisville at sportsbooks monitored by Over their last 16 games as a road favorite, the Seminoles are 15-1 SU.

With 419 passing yards and two passing touchdowns, freshman quarterback Deondre Francois helped lead the Seminoles to a 45-34 come-from-behind win over Ole Miss in the team's home opener. Running back Dalvin Cook had 192 total yards in that game as the offense bailed out a defense that didn't have its best effort in the first half but has allowed only 14 points in the six quarters since.

The Seminoles defeated Charleston Southern 52-8 last Saturday in a tuneup for this week's action.

The Seminoles are 3-1 SU and 2-2 ATS in their last four games against Louisville per the OddsShark College Football Database. Since the Cardinals have joined the ACC, Florida State is 2-0 SU and ATS against them with back-to-back double-digit victories.

Betting Line / Total: Florida State -1 / 68 Points

Trend: Louisville is 2-5 ATS in its last seven games against its conference.

Trend: Florida State is 5-2 ATS in its last seven games on the road.

Through the first two games of the season, the Louisville Cardinals lead the nation in offense with 66 points per game and 754 yards per game. Lamar Jackson has already racked up over 1,000 total yards with 13 total touchdowns. If Jackson can produce against a team of Florida State's caliber this Saturday and lead Louisville to a victory, he should find himself firmly in the Heisman Trophy conversation next week.

The Cardinals are 4-0 SU and ATS in their last four games overall and 6-0 SU in their last six games at home. Saturday's total is set at 68 points. The UNDER is 6-0 in Florida State's last six games on the road.

In six games as a home underdog since 2009, Louisville is 0-6 SU and 1-5 ATS. A win over No. 2 Florida State on Saturday would be one of the biggest wins in the history of the program. For the Seminoles, a road win against an elite team would solidify Florida State's status as a playoff contender and give Deondre Francious plenty of confidence moving forward.

Florida State Seminoles at Louisville Cardinals

When: Saturday, September 17, 12:00 p.m. ET

Where: Papa John's Cardinal Stadium, Louisville, Kentucky

Seminoles at Cardinals OddsShark Matchup Report