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10 college football opening lines: Michigan, Clemson favored in huge Week 5 games

Wisconsin at Michigan, Stanford at Washington, and Louisville at Clemson highlight the Week 5 college football odds slate at the sportsbooks.

Rick Osentoski-USA TODAY Sports

The Michigan Wolverines are 5-5 straight up and 6-4 against the spread in their last 10 home games against Big Ten opponents. The Wolverines will try to improve on their home record against conference opponents this Saturday hosting the Wisconsin Badgers.

Michigan is a 10.5-point betting favorite at the Big House at sportsbooks monitored by Both of these teams have stormed out to 4-0 SU and 3-1 ATS starts, setting the stage for this key Big Ten showdown between two teams ranked in the Top 10.

Wisconsin is 3-1-1 ATS in its last five road games against Michigan, winning its last road game against the Wolverines, 48-28, back in 2010.

In what might be an even bigger game on Saturday, the Louisville Cardinals visit the Clemson Tigers in a game that could ultimately decide which team come out on top in the ACC. The Tigers have won their last 18 straight games at home and are 5-0 SU and 4-1 ATS in their last five games played in Week 5.

Louisville has averaged a remarkable 63.5 points per game en route to a perfect 4-0 SU and ATS start to the season. The Tigers are listed as a 2-point favorite at home.

College Football Week 5 Betting Lines (see the complete list at

  • Kentucky at Alabama (-34)
  • Connecticut at Houston (-28.5)
  • Texas A&M (-17) at South Carolina
  • Baylor (-16.5) at Iowa State
  • Wisconsin at Michigan (-10.5)
  • Stanford at Washington (-3.5)
  • Tennessee (-3.5) at Georgia
  • Texas (-3) at Oklahoma State
  • Louisville at Clemson (-2)
  • Utah at California (-1)

Leading into the weekend's action, the Stanford Cardinal visit the Washington Huskies in a battle between two playoff hopefuls in the Pac-12 on Friday night. Washington is 7-0 SU and 5-2 ATS over its last seven games overall and is going off as a 3.5-point favorite over the Cardinal at home.

Stanford is 12-1 SU and 10-3 ATS in its last 13 games against opponents with a winning record, per the OddsShark College Football Database.

On Thursday night, the Houston Cougars are a 28.5-point favorite at home against the Connecticut Huskies. Houston is 18-1 SU and 13-6 ATS over its last 19 games, but the one outright loss over that stretch came on the road against these Huskies last season as a 7.5-point road favorite.

The Cougars have won their four games this season by an average margin of victory of 34.3 points per game and should be fueled by revenge in this primetime matchup.