The duo both start in a 4-2-3-1 along with Nani on the left wing, with Ryan Giggs and Paul Scholes not in the starting eleven. Phil Jones partners Rio Ferdinand in defence, while Rafael and Tom Cleverley return to the starting lineup. Shinji Kagawa is on the bench.
Fulham keep two of their new signings on the bench, with Emmanuel Frimpong and Urby Emanuelson not yet deemed ready to start for the Cottagers. Former United striker Dimitar Berbatov is injured, so Bryan Ruiz and Hugo Rodallega start up front, with Mladen Petric on the bench.
Fulham (4-4-2): Mark Schwarzer; Sascha Riether, Brede Hangeland, Philippe Senderos, John Arne Riise; Ashkan Dejagah, Chris Baird, Giorgios Karagounis, Damien Duff; Bryan Ruiz, Hugo Rodallega.
Manchester United (4-2-3-1): David De Gea; Rafael, Rio Ferdinand, Phil Jones, Patrice Evra; Michael Carrick, Tom Cleverley;Nani, Wayne Rooney, Antonio Valencia; Robin van Persie.