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San Francisco 49ers at Arizona Cardinals: betting odds, preview, trends, pick

The 49ers have dominated the Cardiinals and catches them with injuries galore here in Week 8. The spread has climbed to -7 and lots of money is going behind San Francisco.

Otto Greule Jr

The San Francisco 49ers are 7-3 SU and 7-2-1 ATS in their last 10 games against the Arizona Cardinals, and will look to continue that success when they visit their division rival this Monday night at the University of Phoenix Stadium.

San Francisco opened as a 4.5-point road favorite at most sportsbooks, but Bovada had the 49ers and -7. "The arly trend was towards the 49ers as we had them running about 70 percent as of Wednesday," said sportsbook manager Kevin Bradley.

San Francisco found itself in the middle of one of the most controversial finishes of Week 7 last week when Coach Jim Harbaugh declined a safety to take over on downs against the Seattle Seahawks. The 49ers locked up the game 13-6 with a kneel-down, but failed to cover the 7.5-point spread as a result of Harbaugh's decision.

With the win, San Francisco improved to 5-2 SU and fell to 4-3 ATS, adding yet another dominant defensive performance to its 2012 resume (allowing just 14.3 points per game).

It has been the tale of two seasons for the Arizona Cardinals here in 2012. Through the first four games of the season, Arizona was one of the league's biggest surprises with a 4-0 SU and 3-1 ATS record including outright upsets over Philadelphia and New England.

But over their last three games, the Cardinals are 0-3 SU and 0-2-1 ATS. With Kevin Kolb and Ryan Williams out, Arizona's offense is averaging just 11 points per game over the three losses.

Both defense-first teams, San Francisco and Arizona have both trended towards the UNDER this season as San Francisco is 2-4-1 on the UNDER and Arizona is 1-6. Four of the last six games between these two teams has gone UNDER the posted total.

On paper, San Francisco's superior offense gives the 49ers a clear edge. But Arizona is a tough home team with an 8-1 SU record in its last nine home games, and in a game that figures to be a defensive struggle, we have trouble passing on a 7-point home underdog in a division rivalry game.

Look for Arizona's defense and special teams to find a way to keep this one close.

PICK: Arizona +7 (courtesy of - follow us on Twitter for line and injury updates)