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Week 10 NFL preview: Panthers vs. 49ers

Two of the best defenses in the NFC. Two of the most exciting and physical young quarterbacks in the game. Two run-first teams fighting for playoff position. Carolina at San Francisco could be the best game of Week 10. Matt Ufford and the Uffsides crew preview the game and make their picks.

This week's Uffsides Game of the Week features the Carolina Panthers vs. the San Francisco 49ers in a matchup of streaking teams. The Panthers have won four in a row by an average of over 20 points, while the Niners are the winners of five straight by a 22-point margin. Both teams feature top-six defenses and young, exciting quarterbacks in Cam Newton and Colin Kaepernick. The Uffsides crew sees San Fran winning at home but are torn on whether Carolina will cover.