Serious injuries have been a major story during training camp and with teams now forced to reduce their rosters to 75 players, a number of notable players were placed on reserve lists. That means they will be out at least the first six games of the season, and if they were placed on injured reserve, all of 2013.
Here's a roundup of some of the noteworthy names who landed on either injured reserve or the physically unable to perform list.
Players placed on injured reserve will miss the entire 2013 season. The only exception to that rule is players who are given the designation to return. In that case, they can return following the eighth game of the season. Many teams have held off on adding that designation yet.
Bryan Bulaga, OT, Packers -- Bulaga tore his ACL during a training camp scrimmage and was placed on IR by Green Bay on Tuesday. There was some initial hope Bulaga would still be able to play this season, but the Packers will now have to do without their starting left tackle for the remainder of the season.
DuJuan Harris, RB, Packers -- Harris was in the mix to start at running back and would likely have been at least a significant contributor this season. He suffered a knee injury in the third preseason game.
Jesse Williams, DT, Seahawks -- Williams dropped to the fifth round of the draft largely due to the knee injury he suffered at Alabama. Seattle selected him and he was penciled in to start at one point. The injury, however, continued to limit him and the Seahawks decided to put him on IR to give him a full year to recover.
Dion Lewis, RB, Browns -- Cleveland placed Lewis on IR on Monday due to the broken leg he suffered in the team's second preseason game. Lewis was in line to back up Trent Richardson this season in addition to a role on special teams.
Montario Hardesty, RB, Browns -- Hardesty had knee surgery early in camp, although he was initially expected to only miss a couple of week during the regular season. Instead, he joined Lewis on IR, leaving the Browns thin at running back.
Physically Unable to Perform
Players placed on the PUP list will sit out at least the first six games of the regular season. They can begin practicing following the sixth game and be activated at any point after that. A player must begin practicing before the 11th game. They he has 21 days to be activated or he is ineligible to return. That means players on the PUP list could return as soon as the seventh game or as late as the 15th game of the season.
Michael Crabtree, WR, 49ers -- The 49ers placed Crabtree on the PUP list while he continues to recover from an offseason Achilles' tendon injury. The move was not a surprise and Crabtree isn't likely to return until late in the season, if at all. San Francisco also placed wide receiver Mario Manningham on the PUP list.
Percy Harvin, WR, Seahawks -- The Seahawks still don't know when or if Percy Harvin will play this year due to a hip injury, but the team is leaving the possibility of a return open. Harvin was placed on the PUP list on Tuesday. Pete Carroll previously said the team wouldn't know Harvin's status for the season until a couple of weeks into the year.
Jay Ratliff, DT, Cowboys -- When Ratliff strained his hamstring during a pre-training camp conditioning drill, the Cowboys didn't seem overly concerned. Ratliff, however, will miss at least the first six games of the year due to the injury and may also be plagued by the groin injury he had surgery on last year.
Jonathan Stewart, RB, Panthers -- The injury-plagued Stewart landed on the PUP list while he continues to rehab from offseason surgery on both ankles. Without him, DeAngelo Williams and rookie Kenjon Barner will likely carry the load for the Panthers.
Jameel McClain, LB, Ravens -- McClain's recovery from a spinal contusion has been slow. He was originally optimistic he'd return for offseason workouts, then the start of training camp. Now, he'll sit out at least the first six games of the regular season.