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NFL odds: Saints, Seahawks Week 5 betting favorites

The New Orleans Saints will be looking for a much-needed home win this weekend in one of the marquee games on the NFL Week 5 odds board.

The New Orleans Saints are 21-3 straight up and 20-3-1 against the spread in their last 24 games as a home favorite. In need of a win this Sunday, the Saints host the Tampa Bay Buccaneers at the Mercedes-Benz Superdome. New Orleans is the biggest favorite on the board this week at -10.5, according to sportsbooks monitored by The Saints are 9-0 SU and 8-0-1 ATS in their last nine games at home, while the Buccaneers are 2-8 SU and ATS in their last 10 road games against division rivals.

Both teams are 1-3 SU and ATS so far this season.

Baltimore vs. Indianapolis should be a great matchup between two hot teams. Baltimore is 3-0 SU and ATS over its last three games, and Indianapolis is 2-0 SU and ATS over its last two. The Colts are 7-2 SU and 8-1 ATS in their last nine games against Baltimore and are a 3.5-point home favorite this Sunday.

The total has gone UNDER in nine of the last 10 games between Indianapolis and Baltimore.

The Kansas City Chiefs are a 6.5-point road underdog at sportsbooks monitored by this Sunday heading into San Francisco. Kansas City is 3-0 ATS in its last three games as a road underdog and 3-0 ATS in its last three road games against NFC West opponents as well. San Francisco is 0-4 ATS in its last four games as a home favorite.

New England hosts Cincinnati this Sunday and is in need of a win after losing 41-14 to Kansas City on Monday night. The Bengals are a 1-point favorite on the road and are 9-3 ATS in their last 12 games against the Patriots. New England is 10-0 SU and 7-3 ATS in its last 10 games at home.

On Monday night, the Seattle Seahawks visit Washington as a 7-point road favorite. Seattle is 7-2 SU and 6-3 ATS in its last nine games as a road favorite and 3-1-1 ATS in its last five games against Washington. Washington is 1-5 SU and 2-4 ATS in its last six games as a home dog.