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49ers vs. Saints: Betting odds, preview and prediction for 'Sunday Night Football'

New Orleans hosts San Francisco in important matchup between NFC contenders.

Streeter Lecka

The New Orleans Saints are 11-0 SU and 9-1-1 ATS over their last 11 games at home. The Saints will try to add another home win to the streak this Sunday hosting the San Francisco 49ers.

New Orleans is a 4.5-point home favorite at sportsbooks monitored by With San Francisco slumping on offense and the Saints' impeccable home record, New Orleans seems to be the play at -4.5 despite the computer's prediction of a closer result.

A 1-3 SU and ATS start to the season had many fans and bettors writing off the New Orleans Saints, but the team has bounced back with a 3-1 SU and ATS record over its last four games. And playing in the lowly NFC South, 4-4 SU is actually good for first place in the division through the first half of the season. A statement 44-23 win over Green Bay at home followed by the team's first road win last Thursday against Carolina appear to indicate that the Saints have turned a corner in recent weeks.

OddsShark Computer Prediction: San Francisco 23, New Orleans 25.6

The Saints host San Francisco at 1 p.m. ET at the Mercedes-Benz Superdome on Sunday.

Since opening the season with a strong 28-17 road win against the Dallas Cowboys, the San Francisco 49ers are just 3-4 SU and 2-5 ATS. Quarterback Colin Kaepernick has struggled over the last two games with just two touchdown passes total in back-to-back losses against Denver and St. Louis. Kaepernick's two fumbles cost the 49ers the game in a stunning 13-10 loss at home against the Rams last week. The 49ers are just 1-4-1 ATS in their last six games as road underdogs.

Sunday's total is set at 49 points at sportsbooks monitored by The OVER is 3-1 in the last four games between the 49ers and the Saints.

Motivation won't be an issue for either team in this game as both teams hope to avoid falling to below .500 and need wins to stay in the playoff hunt. New Orleans is an incredible 26-4 SU and 24-5-1 ATS in its last 30 games as a home favorite, and the 49ers' recent form doesn't appear good enough to hand New Orleans a rare home loss as a 4.5-point favorite.