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NFL Odds: Opening spreads for Week 17 betting

Denver is one of many teams with something to play for this Sunday in Week 17.

Andrew Weber-USA TODAY Sports

The Denver Broncos are 6-0 SU and 5-1 ATS in their last six games against the Oakland Raiders. With one more win against the Raiders at home this week, the Broncos can lock up a first-round bye in the NFL postseason.

Denver is the biggest favorite on the board this Sunday going off at minus-14 against the Raiders at sportsbooks monitored by This will be the fifth straight game in which the Broncos are favored by double-digits over their AFC West rival. Oakland has won three of its last five games, but those three wins have come at home; Oakland is just 1-18 SU over its last 19 road games with a 10-9 ATS record over that stretch.

The Seattle Seahawks host the St. Louis Rams this Sunday and can clinch home field throughout the playoffs with a win. The Seahawks are 9-1 SU and 7-3 ATS over their last 10 home games and 14-2 SU and ATS over their last 16 divisional home games. The Rams meanwhile are just 1-4 SU and ATS over their last five games against NFC West opponents. Seattle is a 13-point home favorite this Sunday on the Week 17 NFL betting lines.

The winner of Sunday's Detroit Lions at Green Bay Packers game will also be earning a first-round bye this weekend. Both teams have clinched a playoff spot at 11-4 SU, but the winner of this game will secure a first-round bye while the loser will be on the road for the first round next week. Green Bay is undefeated at home this year with a 7-0 SU and 5-1-1 ATS record and is a 7.5-point home favorite at the sportsbooks.

Arizona visits San Francisco on Sunday and will be looking for answers on offense before the playoffs begin. Rookie Logan Thomas is expected to take over at quarterback for an offense that has gone two straight games without scoring a touchdown. San Francisco is 9-3 SU and ATS in its last 12 games against Arizona, according to the OddsShark NFL Database, but just 1-8 ATS in its last nine games at home. Arizona is 7-4 SU and 7-3-1 ATS in its last 11 road games and is a 6-point underdog this week.