The 11-seed Dayton Flyers are 8-3 ATS and 7-4 SU in their last 11 games as the betting underdog and they play the same role Thursday in Sweet 16 betting.
Dayton faces 10-seed Stanford, while later in the evening, the 1-seed Florida Gators take on the 4-seed UCLA Bruins as a 4.5-point favorite.
Two days after pulling off a thrilling one-point upset over Ohio State, Dayton did it again against Syracuse, topping the Orange, 55-53, as an 8.5-point underdog.
The Flyers are now 4-2 SU and ATS in their last six games as an underdog. Overall, Dayton is 6-1 SU and ATS over its last seven games.
Stanford has also collected two upsets to earn its trip to the Sweet 16, beating Kansas 60-57 as a 6-point underdog on Friday. The Cardinal are 5-1 SU and 3-2-1 ATS over their last six games.
The total has gone UNDER in six of Stanford's last seven games including each of its last four. In the only other 11-seed vs. 10-seed matchup since 1996, 11-seed VCU beat 10-seed Florida State.
Thursday's South Region action kicks off at the FedExForum in Memphis, Tennessee with Dayton vs. Stanford at 7:15 p.m. ET. Shortly afterward is the UCLA vs. Florida betting matchup at 9:45 p.m.
Florida made quick work of Pittsburgh in a 61-45 blowout win, improving to 28-0 SU over its last 28 games and 6-2 ATS over its last eight. The Gators are a perfect 6-0 SU in their last six Sweet 16 games with a 4-2 ATS record over that stretch.
Florida is 3-0 SU and ATS against the Bruins in three tournament meetings since 2006.
UCLA picked up a 77-60 blowout win over Stephen F. Austin on Sunday to improve to 5-0 SU and ATS over its last five games. The Bruins are 4-1 SU and ATS in their last five games as an underdog.
UCLA has struggled in the Sweet 16 with a 1-7 ATS record since 1997.