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Bills vs. Patriots 2016 odds: Hobbled New England seeks another payout against Buffalo

The New England Patriots will play their final game without starting quarterback Tom Brady this Sunday hosting the Buffalo Bills.

Winslow Townson-USA TODAY Sports

The New England Patriots are 23-2 straight up and 15-8-2 against the spread in their last 25 games against the Buffalo Bills. The Patriots can stay undefeated with another win over the Bills this Sunday in New England.

New England is a 4.5-point home favorite over the Bills at sportsbooks monitored by OddsShark.com. In the last five meetings between these two teams, the Patriots are 3-1-1 ATS.

Down to their third-string quarterback last Thursday night at home against the Houston Texans, the Patriots put together their most complete game of the season. New England racked up 185 rushing yards on offense and allowed only 284 total yards on defense in a 27-0 shutout win to improve to 3-0 SU and ATS on the season.

Jimmy Garoppolo has seen limited action in practice this week with a shoulder injury and is expected to be a game-time decision for New England on Sunday, with Jacoby Brissett (thumb) expected to be ready to go again if Garoppolo is unable to start.

Since the start of the 2011 season, New England is 15-1 SU and 8-6-2 ATS in 16 home games against AFC East opponents per the OddsShark NFL Database. The Patriots are 9-0 SU in their last nine games played in the month of October.

Betting Line / Total: New England -4.5 / OFF

Trend: The Bills are 2-23 SU in their last 25 games against the Patriots.

Trend: The Patriots are 4-0 ATS in their last four games at home.

Buffalo was able to avoid a disastrous 0-3 SU start to the season last Sunday with an impressive 33-18 win at home against the Arizona Cardinals. After scoring just seven points in a 13-7 road loss to the Baltimore Ravens in the team's season opener, the Bills offense has bounced back with 31 points against the New York Jets and 33 points last week against Arizona.

However, the Bills are just 8-25 SU in their last 33 games coming off a win and 2-12-1 ATS in their last 15 games coming off an upset win.

The Bills staff has a tough task this week in needing to prepare game plans for both Brissett and Garoppolo as the offense has looked very different under each quarterback. Regardless of who starts for the Patriots however, Buffalo will be glad to not see Tom Brady under center as the star quarterback serves the final game of his suspension.

Buffalo Bills at New England Patriots

When: Sunday, October 2, 1:00 p.m. ET

Where: Gillette Stadium, Foxborough, Massachusetts

Bills at Patriots OddsShark Matchup Report