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Patriots vs. Cardinals 2016 odds: New England primetime betting underdog against Arizona

The New England Patriots will try to win without Tom Brady this Sunday night when they take on the Arizona Cardinals as road underdogs.

Streeter Lecka/Getty Images

The New England Patriots are 5-1 straight up and against the spread in their last six games against the Arizona Cardinals. The Patriots hope to keep that success going this Sunday night on the road in Arizona.

New England is a 6-point road underdog against the Cardinals at sportsbooks monitored by OddsShark.com. The preseason line on this game had the Patriots as a 1-point favorite, but that shifted heavily upon the suspension of Tom Brady.

With Tom Brady out for the first four games of the regular season, Jimmy Garoppolo will be under center on Sunday against Arizona. Garoppolo was serviceable in the preseason, completing 66.7% of his passes and passing for one touchdown with no interceptions as New England went 3-0 SU in his three starts.

The 24-year-old will get a much tougher test this week facing an Arizona defense that ranked fifth in total defense and eighth in passing defense in 2015.

Since the start of the 2010 season, the Patriots have been a betting underdog just 16 times. They are 11-5 SU and 12-4 ATS in those 16 games per the OddsShark NFL Database.

Betting Line / Total: Arizona -6 / 46.5 Points

Trend: The Patriots are 5-1 SU and ATS in their last six games against the Cardinals.

Trend: The Cardinals are 7-0 SU in their last seven games in September.

The Cardinals went 13-2 SU and 10-5 ATS through the first 15 games of the regular season in 2015, looking like a legitimate Super Bowl contender every step of the way. But the season ended on a 1-2 SU and 0-3 ATS skid that included two losses by 30 points or more, overshadowing the tremendous year the team had up to that point.

Arizona has been a strong starter over the last three seasons with a 7-0 SU and 6-1 ATS record in their last seven games played in the month of September.

Sunday night's total is set at 46.5 points. The UNDER is 6-1 in New England's last seven games as an underdog.

When Tom Brady went down with a torn ACL in the first game of the 2008 season, the Patriots still proceeded to go 11-5 SU without him. Brady's value to the Patriots can not be understated, but his teammates should relish the opportunity to step up and prove that this is not a one-man team.

New England Patriots at Arizona Cardinals

When: Sunday, September 11, 8:30 p.m. ET

Where: University of Phoenix Stadium, Glendale, Arizona

Patriots at Cardinals OddsShark Matchup Report