Anderlecht don't have a couple of their central defenders available, so they've had to adjust their lineup, which they'll be hoping doesn't look too flimsy against Arsenal. It appears that regular left back Olivier Deschacht will have to move inside to play in the center, and the Gunners have to do something similar to replace Laurent Koscielny, shifting Nacho Monreal inside.
With Mesut Özil and Tomas Rosicky unavailable, Arsenal's lineup will probably look more than a 4-3-3 than a 4-2-3-1. There's no surprise in their lineup, with Aaron Ramsey, Jack Wilshere and Alexis Sanchez all getting starts.
Anderlecht lineup (4-2-3-1): Silvio Proto; Anthony Vanden Borre, Olivier Deschacht, Chancel Mbemba, Andy Najar; Youri Tielemans, Steven Defour; Ibrahima Conte, Dennis Praet, Frank Acheampong; Gohi Bi Zoro Cyriac
Arsenal lineup (4-3-3): Emiliano Martinez; Kieran Gibbs, Nacho Monreal, Per Mertesacker, Calum Chambers; Mathieu Flamini, Jack Wilshere, Aaron Ramsey; Santi Cazorla, Danny Welbeck, Alexis Sanchez
Kickoff is at 2:45 p.m. ET. You can catch the game on Fox Sports 2 in the United States.