Andy Murray and Stan Wawrinka, the men's second and third seeds, are the chief competition at the US Open for top seed Novak Djokovic, along with Rafael Nadal. But to this point, the tournament has been much kinder to Djokovic, as the Serb has played just four complete sets so far and yet has himself a spot in the Round of 16.
Djokovic went four sets in his first match, but skipped his second entirely and played only part of the first set of his third thanks to injuries to his opponents, Jiri Vesely and Mikhail Youzhny.
Murray will try to punch his ticket to the Round of 16 when he faces unseeded Paolo Lorenzi. Wawrinka will take on Daniel Evans. There's no shortage of high seeds still in the tournament, as Kei Nishikori, Dominic Thiem and David Ferrer will all also be in action on Saturday.
Ferrer, though, may have the toughest draw of all, as he is set to face the unseeded Juan Martin Del Potro. The US Open winner in 2009, Del Potro has struggled in recent years but has been on a mighty resurgence, playing some of the best tennis of his career. He eliminated both Djokovic and Nadal from the Olympics and took home the silver medal.
On the women's side, both Serena Williams and Venus Williams will be in action. Serena is still going strong after a disappointing run in the Summer Olympics. She will face unseeded Johanna Larsson on Saturday. Venus will be up against her first seeded opponent of the tournament, No. 26 Laura Siegemund.
Agnieszka Radwanska, one of Serena's top competitors and the fourth seed for the tournament, will face No. 25 Caroline Garcia.
Play on Saturday gets underway at 11 a.m. ET. Television coverage will be carried by ESPN2, beginning at the same time as play. It will run through 11 p.m., going all day. WatchESPN will carry live streams of all the courts. Below is a list of singles matches including seeded competition, and the information you need to watch Saturday's action.
No. 2 Andy Murray vs. Paolo Lorenzi
No. 3 Stan Wawrinka vs. Daniel Evans
No. 6 Kei Nishikori vs. Nicolas Mahut
No. 8 Dominic Thiem vs. Pablo Carreno Busta
No. 11 David Ferrer vs. Juan Martin Del Potro
No. 14 Nick Kyrgios vs. Illya Marchenko
No. 21 Ivo Karlovic vs. Jared Donaldson
No. 22 Grigor Dimitrov vs. Joao Sousa
No. 1 Serena Williams vs. Johanna Larsson
No. 4 Agnieszka Radwanska vs. No. 25 Caroline Garcia
No. 5 Simona Halep vs. No. 31 Timea Babos
No. 6 Venus Williams vs. No. 26 Laura Siegemund
No. 10 Karolina Pliskova vs. No. 17 Anastasia Pavlyuchenkova
No. 11 Carla Suarez Navarro vs. No. 19 Elena Vesnina
US Open tennis coverage for Day 6 on Saturday
All times Eastern
Events: Men's and women's singles third round
Time: 11 a.m.
TV: ESPN2 (11 a.m. - 11 p.m.)
Online Streaming: WatchESPN